Kinetic model for adherent Vero cell growth and poliovirus production in batch bioreactors
نویسندگان
چکیده
منابع مشابه
Mathematical model of adherent Vero cell growth and poliovirus production in animal component free medium.
Sabin-IPV (or sIPV, inactivated polio vaccine based on attenuated Sabin strains) is anticipated to replace the oral polio vaccine for the endgame in polio eradication. Optimization of sIPV production will lead to a better economically feasible vaccine. To assist process optimization, we studied Sabin type 1 poliovirus (PV) infection kinetics on Vero cells in controlled bioreactor vessels. The a...
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متن کاملKinetic characterization of vero cell metabolism in a serum-free batch culture process.
A global kinetic study of the central metabolism of Vero cells cultivated in a serum-free medium is proposed in the present work. Central metabolism including glycolysis, glutaminolysis, and tricarboxylic acid cycle (TCA) was demonstrated to be saturated by high flow rates of consumption of the two major substrates, glucose, and glutamine. Saturation was reavealed by an accumulation of metaboli...
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ژورنال
عنوان ژورنال: Process Biochemistry
سال: 2019
ISSN: 1359-5113
DOI: 10.1016/j.procbio.2019.03.010